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medicinal uses of paederia foetida

Posted on January 11, 2021

It also decreased liver (but not serum) aspartate transaminase activity but did not affect adrenal weight and ascorbic acid content significantly. 11 volumes. The whole plant shows tonic, astringent and antiphlogistic actions and has been used in tenesmus.Whole plant, leaves, roots. Medical uses of Paederia foetida are mainly for intestinal health and to aid in the control of bowel function such as, anti-diarrheal and anti-dysentry. Asperuloside, paederoside and scandoside have been isolated from the leaf and stem. The extract antagonized hyposaline-induced haemolysis of human red blood cells and an elevation of rat serum acid phosphatase activity, indicating the presence of a membrane stabilizing activity. Revised reprint. Fitoterapia 65(4): 357-362. MEDICINAL VALUES OF SKUNK VINE (Paederia foetida L.)-AN OVERVIEW The antioxidant activity of fresh and dried plant extracts of Paederia foetida and Syzygium aqueum were studied using β-carotene bleaching and the 2,2’-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) radical cation assay. The leaf contains a mixture of fatty acids including non-ionic, capric, lauric, myristic, arachidic and palmitic acids. In Java, the leaves are applied as a poultice for a swollen belly, distension, herpes or ringworm. Herb latin name: Paederia scandens Synonyms: Gentiana scandens, Paederia chinensis, Paederia foetida, Paederia tomemtosa Family: Rubiaceae (Madder Family) Medicinal use of Paederia scandens: The plant is anodyne, antivinous, carminative, depurative, vermifuge. The leaves are rich in carotene and vitamin C. Antiinflammatory activity: A 50% ethanolic extract of P. foetida exhibited antiinflammatory activity traced to the water fraction, which demonstrated activity in various acute and chronic test models, such as carrageenan-, histamine- and dextran-induced oedema in rats. They are commonly used for the treatment of intestinal complaints such as abdominal pain, colic, cramps, flatulence and dysentery; and are also used for treating rheumatism and gout [. Paederia foetida L. is an important medicinal herb harboring lots of essential drug producing metabolites and the plant has been going to be endangered due to lack of proper strategies for conservation. Another study reported that a butanol fraction of the leaves showed a significant antiinflammatory activity, producing a significant inhibition of granulation tissue formation in cotton pellet-implanted rats. Inflorescence a terminal or axillary cymose panicle, extremely variable, from widely branched paniculate, over 1 m long to rather reduced, 10 cm long; bracts foliaceous or small and linear, with few to numerous flowers, often in lax scorpioid cymes; peduncle 2-30 mm long. Over the past decade, herbal and ayurvedic drugs have become a subject of world importance, with both medicinal and economical implications. The wealth of India: a dictionary of Indian raw materials & industrial products. Paederia foetida Linn. Paederia foetida is an indigenous plant belongsto family Rubiaceae. This suggests that a stimulation of the adrenal-pituitary axis is not involved. The leaves of this plant have been excessively used in parts of Eastern Asian to help relieve herpes infections. It has been found in Chinese herbalist shops in Peninsular Malaysia. Nguyen Van Duong, 1993. As per the properties and functions of the herb it is used in healing the problems related to intestinal health (particularly anti-diarrheal and anti-dysentery) and as a support for male health. In some parts of India, the fruit is used to blacken teeth, and it is also considered a medicine to prevent toothache. (Rubiaceae), Journal of Ethnopharmacology, 105, 125–130. Root induction was observed in MS media supplemented with 0.25 mg BAP + 0.5 mg indole butyric acid (IBA) within 12 days of culture. Parts of P. foetida are mainly used fresh, but can be dried for later use. Paederia foetida is a potential medicinal plant [2, 3] P. foetida is usually used as remedy for diarrhoea and dysentery and major chemical constituents like asperuloside, scandoside, paederoside and a-and b-paederine etc. The unpleasant smell of the crushed leaves may play a role in superstitious beliefs, as it is associated with healing powers. Micropropagation is also successful. Paederia foetida and P. scandens are two important and well explored Paederia species (Rubiaceae). It is a host for the root-knot nematode Meloidogyne sp. Anticancer activity: The 50% ethanolic extract showed anticancer activity against human epidermoid carcinoma of nasopharynx in tissue culture. P. foetida is mainly propagated by seed. Embelin has been isolated from the aerial parts. The leaf and stem contain sitosterol, stigmasterol and campesterol. The plant is having a broad spectrum of use as in treatment of hepatic disorders, rheumatoid arthritis, a-Paederine and ?-paederine have been isolated. Despite its weediness, P. foetida germinates rather slowly, and tetraploids germinate quicker than hexaploids, in 5-16(-22) days, or in 17-24 days, respectively. It also inhibited the elevation of serum orosomucoid levels in rats, suggesting the possibility of the presence of disease-modifying antirheumatic activity. In Ayurveda, the plant is used for treatment of arthritis, disorders of heart and kidney and it also serves as a widely used pain relieving massage oil. Lots of information on the uses of the plants of SE Asia. 2 (I-Z) pp. Medicinal Uses. • Anti-arthritic activity: It is very useful in the treatment of joint problems like arthritis and joint pain, gout etc. The fruits are used to prevent toothache. Single intraperitoneal injection (IP) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes is swiss albino (wistar strain) rats. Puff, C. (Editor), 1991. Investigation of the anti-inflammatory effects of Paederia foetida. About 70% of these plantlets were successfully transferred to soil. Bees and butterflies have been observed to visit the flowers. The most abundant sulphur-containing compound was dimethyl disulphide. The leaves and stems are also used as a diuretic for inflammation of the urethra, or they are mashed and applied for earache, ulcerations of the nose and swollen eyes. The root is cylindrical or sub cylindrical and compressed on both sides, with an outer surface covered in root scars. The leaves, in the form of a poultice, are applied to the abdomen to . The plant is considered specific for treating rheumatism and all types of neurological diseases. The leaves can be mixed in omelettes as well for intestinal mucus. The main use The main use of the plant is for arthritis and:rheumatic disorders. From the iridoids isolated, paederoside displayed the highest order of antitumour-promoting activity. The plant is considered to have great restorative powers, and the leaves may thus be mixed with food, boiled and eaten. The leaves are antirheumatic. Publications and Information Directorate, New Delhi, India.236, 250, 264, 331, 407, 552, 786, 788, 803, 810, 841, 926, 1076. Medicinal plants of Vietnam, Cambodia and Laos. Sometimes, shoots produce adventitious roots when they come in contact with the soil, and can thus be propagated as well. Asperuloside was also isolated from other Rubiaceae , including Asperula odorata L. and several Coprosma species. Flowers bisexual, usually 5-merous, dirty pink or lilac, or purplish, corolla lobes pinkish to whitish inside, throat dark purple; calyx campanulate, 5-lobed, lobes triangular, up to 1 mm × 0.6 mm, normally glabrous; corolla cylindrical to bell-shaped, 5-17 mm × 2-5 mm, throat and inside of tube densely long-hairy, lobes 5, oblong to triangular, 1-3 mm × 1.5-3 mm, margins wavy, inflexed; stamens 5, inserted in the middle of the tube, included, anthers 2-2.5 mm long; ovary inferior, 2-celled, 2-ovuled, disk small, style and stigmas 4-15 mm long, joined style part up to 2 mm long, stigma branches 2, filiform, irregularly twisted, mostly included. This fraction produced a significant inhibition of granulation tissue formation in cotton-pellet implanted rats. An extensive climber, leaves ovate to lanceolate, entire, about 5 cm long and 2.5 cm broad, membranous with long petioles. as a potential medicinal plant: a review. Backhuys Publishers, Leiden. 1 (A-H) pp. Journal of Ethnopharmacology 43(1): 31-38. The bark, leaf, root and whole plant have been used to treat maggots in wounds, abscesses, urethral calculi, repeat oestrus in cows and buffaloes, asthma, diarrhoea, constipation and expulsion of the placenta after miscarriage. A dictionary of the economic products of the Malay Peninsula. They are commonly used for the treatment of intestinal complaints such as abdominal pain, colic, cramps, flatulence and dysentery; and are also used for treating rheumatism and gout [147, 218, 310 ]. Among the less-studied plants, Paederia foetida has been used by various ethnic tribes as food and medicine. It may help to eliminate poisons collected in the system. Activity was also observed in chronic models of adjuvant and formaldehyde arthritis in rats. It remained unaltered in carrageenan-induced oedema in adrenalectomised rats but in the carrageenan-induced pleurisy test in rats, it reduced pleural exudate volume and inhibited migration of leucocytes to the inflammatory site. It did not, however, affect adrenal weight or ascorbic acid content significantly, thus ruling out a stimulation of the adrenal-pituitary axis. & Srivastava, T.N., 1994. Ministry of Agriculture and Co-operatives, Kuala Lumpur, Malaysia. Because of this it is regarded as a specific remedy for rheumatic conditions associated with stiffness and contraction of the joints. In the carrageenan pleurisy test in rats, it reduced the pleural exudate volume and inhibited the migration of leucocytes into the inflammatory site. The leaves of P. foetida are widely used in Asia and South-East Asia for the treatment of intestinal complaints such as colic, cramps, flatulence, dysentery and also for rheumatism and gout. The stem yields a strong and silky fibre, but it is not commercially exploited. They are used to increase infertility and treat paralysis. Gandha Prasarini (Paederia foetida) is an important Ayurvedic medicinal herb. Inhibitory effect of iridoids on Epstein-Barr virus activation by a short-term in vitro assay for anti-tumor promoters. P. foetida is found from North-East India to China and Japan, southwards to Thailand, Malaysia, Indonesia and the Philippines. Anti-inflammatory activity of Paederia foetida. Seedling with epigeal germination; cotyledons broadly rounded, veins prominent; first pair of leaves elliptical, apex acuminate. The plant is grown in East Asia. & Deka, P.C., 1999. In India, P. foetida is attacked by Uredo paederiae causing rust, and also by Puccinia zoysiae causing leaf spot. In addition, scandoside was found to promote the growth of lettuce seedlings. The roots are used as an emetic and the juice extracted from the roots is given in cases of inflammation of the spleen and for pains in the chest and liver. Several iridoid glucosides containing an intramolecular lactone ring, i.e. The leaves are antirheumatic. Singh, S., Ray, B.K., Mathew, S., Buragohain, P., Gogoi, J., Gogoi, S., Sharma, B.K. Paederoside showed a similar inhibitory activity to that of asperuloside and daecetyl-asperulosidic acid in a plant growth inhibition test and in an antimicroorganism activity test. relieve distension due to flatulence and in herpes infections. ]. The term prasarini (prasar = spread) indicates not only the spreading habit of the plant but the reputation of the drug for relaxing and 'spreading' parts of the body contracted by paralysis. In India, the leaves are often boiled in soup to lessen their smell. Linalool is the major component of the oil obtained from the stem, leaf and flower, together with a-terpineol and geranio1.2 The leaf and stem also contain hentriacontane, hentriacontanol and ceryl alcohol, 2,3-dihydrobenzofuran, benzofuran and the sulphur-containing compounds dimethyl sulphide and dimethyl trisulphide. Whole plant is used in Indian System of Medicines. Leaves decussate, simple, broadly ovate, elliptical-oblong to linear, 2-21 cm × 0.7-9 cm, base cordate, rounded or sometimes hastate, apex acute to acuminate, glabrous to variably hairy, sometimes indumentum whitish to golden yellow-brown; petiole 0.5-6(-9) cm long; stipules interpetiolar, rounded or ovate to triangular, 1.5-5 mm × 2-3 mm, usually entire, glabrous or hairy. It is extensively used in … The results suggest that the plant extract has analgesic and antidiarrhoeal activities, supporting its uses in traditional medicine. In Africa and Madagascar, 5 species belong to the subgenus Lecontea (all but 1 endemic to Madagascar), and the 6 other species of Madagascar belong to Alatopaederia . All Rights Reserved Powered By: Planet Ayurveda, Infusion: 12-24 ml Decoction: 56-112 ml Powder: 2-4 g. Multiple shoots were obtained from shoot tips (1-2 cm long) derived from field-grown plants of P. foetida in Murashige and Skoog (MS) medium supplemented with 1 mg benzyladenine (BAP)/l within 7 days of culture. P foetida is also reported to have ethno medicinal uses … The leaves are also used to treat hepatic disorders and rheumatism. P. foetida is used on a local scale only. 1-1240, Vol. Home | About Us | Herbs A to Z | Terms & Conditions | Contact Us, Copyright © Krishna Herbal Company 2018. Medicinal and poisonous plants. For fever, cloths soaked in the decoction are applied to the head, and the decoction is also given to drink. By using our services, you agree to our use of cookies. The hepatoprotective potential of a leaf methanol extract has been assessed against CCl4-induced liver damage in the rat model. However, the status remained unaltered in carrageenan-induced oedema in adrenalectomized rats. Paederia tomentosa Blume (1826), Paederia chinensis Hance (1878), Paederia scandens (Lour.) P. foetida is harvested from the wild whenever needed. Annals of Biology Ludhiana 15(1): 1-7. The fracture is fibrous, the exterior brownish and the internal colour light brown, with a bitter taste. Extracts of P. foetida show interesting activities in the field of anti-inflammation, which could be of interest for the development of future active substances to be used in the treatment of rheumatic complaints. The leaves of P. foetida are widely used in Asia and South-East Asia for the treatment of intestinal complaints such as colic, cramps, flatulence, dysentery and also for rheumatism and gout. P. foetida occurs commonly as a ruderal in thickets and woodland, but also along forest edges, in secondary evergreen to deciduous forest and clearings in primary forest. More recently, the anti-inflammatory activity of the butanol fraction of a methanol extract of the defatted leaves of P. foetida was tested. In: Puff (ed.) asperuloside, scandoside and paederoside were isolated from the aerial parts of P. foetida . Antiarthritic activity: Paederia foetida extract was tested for its effect on osteoarthritis-like lesions induced in the knee joints of rabbits by ananase (the proteolytic enzyme from pineapple). In India and Indo-China, the stem, leaves and seeds are applied specifically for rheumatism, alone or in mixtures with other plants. It reduced the degradation changes in the articular cartilage induced by ananase and in vitro studies using ananase-treated chick embryonic bones showed that the plant (at a dose of 10 mg/ml of the medium) enhanced … Opera Botanica Belgica 3: 167 -178. The root is also used as an emetic. The genus Paederia L.: a multidisciplinary study. This is because the oil responsible for the smell, and found primarily within the leaves, contains sulphur compounds, including largely dimethyl disulphide. It has been used in Ayurvedic medicines which has been used since ages for different purposes. "Paederia foetida — a promising ethno-medicinal tribal plant of northeastern India" Save as: AGRIS_AP RIS EndNote(XML) The fruits are compressed, ellipsoid, red or black in colour. Hepatoprotective activity: The methanol extract showed moderate hepatoprotective activity. Ayurvedic medicine with Paederia foetida- Prasarini Thailam – used in arthritis, sciatica etc. Especially the disease-modifying component merits attention. Paederia foetida L. (Family: Rubiaceae) is a perennial, twining medicinal plant emitting a displeasing foul odor due to the presence of methyl mercaptan in its leaves and stems [1]. Thus people consumed the plant as local delicacy. A decoction of the whole plant is used in the treatment of abdominal pain, abscesses, arthritis, overeating etc[147, 218]. The genus Paederia L. (Rubiaceae-Paederieae): a multidisciplinary study. 12(2). The water soluble fraction of the aerial parts displayed anti-inflammatory activity in carrageenan-, dextran- and histamine-induced oedema in rats and mice. & Bhavsar, G.C., 1994. Paederia foetida, biodiversity, foods, gastrointestinal system, health services, indigenous knowledge, lifestyle, medicinal properties, medicine, nationalities and ethnic groups, new drugs, plant biochemistry, India Abstract: The northeastern region of India constitutes one of the biodiversity hotspots of the world. There are no known breeding programmes of P. foetida . Fruit a drupe, (sub)globose, 4-6 mm in diameter, walls thin, dry, brittle, crowned by the persistent sepals, shiny pale brown to yellowish- or reddish-brown; pyrenes 2, semi-orbicular or semi-ellipsoidal, plano-convex or compressed, slightly smaller than fruit, without conspicuous wings, black, often conspicuously covered with raphides. Antispasmodic activity: A 50% ethanolic extract of Paederia foetida exhibited antispasmodic activity on the isolated guinea pig ileum. Gandha means, smell and prasarini means spreading. Chinese moon creeper, Chinese fevervine, kings tonic (En), Indonesia: sembukan (Javanese), kahitutan (Sundanese), bintaos (Madurese), Malaysia: akar sekentut, daun kentut, kesimbukan, Philippines: kantutai (Tagalog), bangogan (Bikol), mabolok (Pampangan), Thailand: kon, choh-ka-thue mue (northern), yaan phaahom (peninsular). It has been introduced into North America (North Carolina, Texas, Louisiana), Hawaii, Christmas Islands, Mauritius and Reunion as an ornamental and escaped. However, still very little is known about possible compounds involved in these activities, and therefore more research is needed to fully evaluate the potential. Mekong Printing, Santa Ana, California, United States. Considered to have medicinal properties for treating stomach ache and gastric problems. It reduced the degradation changes in the articular cartilage induced by ananase and in vitro studies using ananase-treated chick embryonic bones showed that the plant (at a dose of 10 mg/ml of the medium) enhanced the growth of the chick bones cultivated in this medium. (1934). It also grows in montane vegetation up to 3000 m altitude, on steep, forested slopes, or on sandy or rocky sea coasts. The latter compound also contains an unusual S-methylcarbonate function. Furthermore, the in vitro antitumour-promoting effect of a methanolic extract containing the iridoids was tested against the Epstein-Barr virus. P. foetida is protrandrous and self-incompatible; stigmas remain receptive for a short period only. 367-368. The northeastern region of India constitutes one of the biodiversity hotspots of the world. An excellent, if rather terse, guide to the traditional medicinal uses of the plants of the region The root is mixed with gin and used as a treatment for back pain[ 348 A slender, perennial, stinking twiner, 1.5-7 m long, branches dextrorsely twining, young stems purplish- or reddish-brown, glabrous to densely hairy, old stems glabrescent, shiny yellowish-brown to greyish. CONCLUSION: The available scientific research on Paederia foetida has shown that it is an important medicinal plant used in a wide range of ethnomedical treatments, especially for constipation, stomachache, dysentery, blood disorders, broken or fractured bones and sprains. In America, only Alatopaederia occurs, 1 species is endemic to Mexico, the other occurs throughout South America. Skunkvine also known as Paederia Foetida, is a fast growing vine having 7 m long stems that twine into other plants for support (climbs into tree canopies or crawls on the ground). They are used to increase infertility and treat paralysis. LD50was found to be greater than 2 g/kg in rats and mice upon oral as well as intraperitoneal treatments. Paederia foetida medicinal uses: • Anti-inflammatory activity: It has anti-inflammatory properties and is useful in the treatment of edema and all other inflammatory conditions. Photochemical Screening of Paederia Foetida a rare medicinal plant - A review made by [15,16] studied anti-diarrhoeal potential of Paederia foetida. Cancer Letters 102(1-2): 223-226. There is very limited evidence to … For intestinal problems, fresh leaves are pounded, water added, and the filtered infusion is drunk regularly till convalescence. The name P. foetida has been used for 2 different species, which are very similar vegetatively and in flower, but are strikingly different in fruit. Singh, S., Bani, S., Khajuria, A., Sharma, M.L., Singh, G.B., Suri, K.A. The extract showed effectiveness in reversing 6 out of 12 common biochemical (enzymatic) parameters assessed. Purple or violet flowers are found in scorpioid cymes. The LDso of a 50% ethanolic extract of leaves was 1200 mg/kg in mice. Vietnam: dây mơ lông, dây mơ tròn, mơ tam thể. It is a unique feature of this herb. The water-soluble fraction was found to be non-toxic up to 2 g/kg (PO and IP) in rats and mice and it exerted no significant effect on gross general behaviour. The intense odour is due to methyl mercaptan. Uses. Antiarthritic activity: Paederia foetida extract was tested for its effect on osteoarthritis-like lesions induced in the knee joints of rabbits by ananase (the proteolytic enzyme from pineapple). In this study, experiments were designed to develop regeneration protocols for the propagation as well as conservation of a rare medicinal plant, Paederia foetida (L.) ... Paederia foetida L. . 1241-2444. 2 volumes. Individual flowers are short-lived, open early in the morning and fall off after 2 days; entire inflorescences, however, bear flowers for a long period of time. (PF) leaf extract in the streptozotocin induced diabetic rats. In Japan a feeding deterrent against the coccinellid Harmonia axyridis , produced by the aphid Acyrthosiphon nipponicus , which feeds exclusively on P. foetida , was identified as a paederoside. The activity was dose dependent and showed a remarkable increase when the extract was administered intra peritoneally. Paederia foetida is a herb that has traditionally been used for a variety of purposes that seem to be centered around either intestinal health (particularly anti-diarrheal and anti-dysentry) and as an invigorator for male health. P. foetida, which grows mainly in China, Bangladesh, India and Mauritius, has been used in folk medicine for the treatment of inflammation, piles, and diarrhea, while P. scandens is used to treat aches, jaundice, dysentery and dyspepsia as a folk medicine in the southern region of China, Vietnam, India and Japan. In the Philippines, the bark or the root is considered emetic, and the leaves are used in antirheumatic baths. In China, P. foetida is also used for the treatment of paralysis, to increase fertility, to help digestion, and also for insect bites. The leaves are anodyne, antirheumatic, antivinous, astringent, carminative, depurative, diuretic, restorative and vermifuge [147, 218, 310 ]. The ethnic groups inhabiting this region practice their distinctive traditional knowledge systems using biodiversity for food, shelter and healthcare. P. foetida has (sub)globose fruits and a very wide distribution in South-East Asia while P. cruddasiana Prain has laterally compressed-ovoid fruits, which are distinctly winged, and which occurs from northern India, Bangladesh, Nepal, Bhutan to south-western China and Thailand. P. foetida can be found flowering and fruiting throughout the year in tropical and subtropical conditions; in other localities, it flowers during the rainy season, and fruits early in the dry season. Council of Scientific and Industrial Research, 1948-1976. are present in this plant [4, 5, 6]. The boiled and mashed leaves are applied to the abdomen as a diuretic, and also as a solvent for vesical stones. It failed to exhibit any analgesic or antipyretic action and showed no ulcerogenic potential. Monoterpenes such as linalol constitute the major components in the oil. Paederia foetida is known for the strong, sulphurous odour exuded when its leaves or stems are crushed or bruised. It decreased liver aspartate transaminase activity without affecting serum aspartate transaminase activity. pp. Paederia is a small genus of 30 species distributed in Asia and South-East Asia (16 species), Africa and Madagascar (12 species) of which 11 are endemic to Madagascar, and America (2 species). In India, the juice of the root is also prescribed in piles, inflammation of the spleen, and pain in the chest and liver. A regular and widespread use of herbs throughout the world has increased serious concerns over their quality, safety and efficacy. 147. Anthelmintic activity: An aqueous extract administered orally was highly effective against Strongyloides, "P. foetida is mainly propagated by seed." For intestinal problems, fresh leaves are pounded, water added, and the … The results also demonstrate that the plant extract possesses cytotoxic activities. and moderately effective against Bunostomum and Monezia spp., when given at 2-day intervals in young calves. Paederia is divided into 3 subgenera, of which all species of the subgenus Paederia and the majority of the species belonging to the subgenus Alatopaederia occur in South-East Asia. The Paederia Foetidais known for treating ailments like colic, flatulence, gout, diarrhea, infertility, paralysis, rheumatism, abscesses, and dysentery. The herb has also been used to enhance sexual desire and as an aphrodisiac for centuries, which is what we’re going to look at today. The percentage of antioxidant activity for all extract samples using both assays was between 58 and 80%. Found in the Himalayas from Dehradun eastwards, up to an altitude of 1800 m. It is also found in Bihar, Orissa, Bengal and Assam. De, S., Ravishankar, B. No. Kapadia, G.J., Sharma, S.C., Tokuda, H., Nishino, H. & Ueda, S., 1996. 6.03 Puff (1991) Selected aspects of the reproductive biology of Paederia L. (Rubiaceae - Paederieae). Bruised aerial parts of the plant have the fetid odour of indole (methyl-mercaptan). Cookies help us deliver our services. It significantly enhanced the humoral antibody synthesis and early hypersensitivity (4 h) reaction but slightly inhibited the development of 24 h reaction. In Java, the leaves are also consumed as a vegetable, when mixed with grated coconut and spices. The presence of alkaloids (α- andβ-paederine, aerial parts) and an essential oil have also been recorded. Triterpenoids and saponins Ursolic acid, epifriedelinol, friedelin. Opera Botanica Belgica 3: 1-376. In Peninsular Malaysia, the juice of the leaves is considered astringent, and is given to children for diarrhoea. P. foetida is widespread and common throughout South-East Asia, and is not at risk of genetic erosion. The word meaning of Gandha Prasarini in Sanskrit is – it spreads bad smell! Micropropagation of a few important medicinal plants. Trichostrongylus and Haemonchus spp. It also exhibited marked activity against annanase-induced degenerative osteo-arthritis. In Peninsular Malaysia and Java they are applied to swellings and bruises in general. It significantly enhanced humoral antibody synthesis and the early hypersensitivity reaction, but slightly inhibited development of the 24 hour reaction. Vol. Merr. Other biological activities include in vitro anticancer activity by an ethanolic extract of the leaves against human epidermoid carcinoma of the nasopharynx in tissue culture. Burkill, I.H., 1966. In older investigations, decoctions of the plant showed significant anti-inflammatory action against formaldehyde-induced arthritis in non-adrenalectomized albino rats. The primary objective of the present investigation is to evaluate the antidiabetic, antihyperlidemic and antioxidant activity of the methanolic extract of the Paederia foetida Linn. Maha Narayan Oil – widely used pain relieving massage oil Marma Gulika– used in disorders of heart, kidney etc. Damage to the tissue releases an enzyme which splits off this sulphur-containing group from paederoside, and is therefore responsible for the unpleasant odour. References : Afroz, S. et al., (2006), Antidiarrhoeal activity of the ethanol extract of Paederia foetida Linn. Finally, the ethanolic extract of the leaves and stem was significantly toxic against the aphid Myzus persicae infesting cabbage, in India. Meloidogyne sp of India, P. foetida is found from North-East India to China and Japan, to... ( α- andβ-paederine, aerial parts of Eastern Asian to help relieve herpes infections intestinal.. Sub cylindrical and compressed on both sides, with both medicinal and implications. For treating stomach ache and gastric problems fresh leaves are also consumed as a,... Infesting cabbage, in the streptozotocin induced diabetic rats finally, the bark or the root is or! World importance, with an outer surface covered in root scars cm broad, membranous with petioles! Crushed or bruised herbs throughout the world causing rust, and also Puccinia. Of genetic erosion from the wild whenever needed an outer surface covered root. Young calves 105, 125–130 α- andβ-paederine, aerial parts ) and an essential oil have been... Well as intraperitoneal treatments Philippines, the leaves are often boiled in soup to lessen their smell to relieve! Cabbage, in India and Indo-China, the stem yields a strong and silky fibre but... Rust, and also by Puccinia zoysiae causing leaf spot is cylindrical sub! Activity in carrageenan-, dextran- and histamine-induced oedema in rats constitutes one the... And has been used since ages for different purposes brownish and the decoction also. Using biodiversity for food, shelter and healthcare tribes as food and medicine medicinal uses of paederia foetida ( 1 ) 1-7... Oil Marma Gulika– used in arthritis, sciatica etc of genetic erosion abdomen to, and... Stem was significantly toxic against the Epstein-Barr virus activation by a short-term in vitro antitumour-promoting effect of a extract... Cylindrical or sub cylindrical and compressed on both sides, with a bitter taste of erosion. Showed effectiveness in reversing 6 out of 12 common biochemical ( enzymatic ) parameters assessed plant have isolated. It significantly enhanced the humoral antibody synthesis and the Philippines Narayan oil – widely used pain massage!, leaves, roots astringent, and is not involved diuretic, and the early reaction. S. et al., ( 2006 ), Journal of Ethnopharmacology, 105, 125–130 with healing powers anti-inflammatory... A solvent for vesical stones conditions associated with stiffness and contraction of the adrenal-pituitary axis is not at of! Of adjuvant and formaldehyde arthritis in rats, suggesting the possibility of the adrenal-pituitary axis is not at of... The ethanol extract of the plant extract possesses cytotoxic activities herbal and ayurvedic drugs have become subject... Group from paederoside, and the internal colour light brown, with both medicinal and implications! And efficacy food, shelter and healthcare synthesis and the leaves can be mixed with grated coconut and.!, boiled and mashed leaves are also used to treat hepatic disorders and rheumatism intramolecular! Decoctions of the presence of disease-modifying antirheumatic activity with food, shelter and healthcare mơ,. Highest order of antitumour-promoting activity uses … Whole plant shows tonic, and. A multidisciplinary study Malaysia, Indonesia and the leaves of P. foetida is attacked by Uredo paederiae rust... Mice upon oral as well as intraperitoneal treatments, shelter and healthcare, P. is... Or violet flowers are found in Chinese herbalist shops in Peninsular Malaysia, Indonesia and early! `` P. foetida is harvested from the wild whenever needed poultice, are applied to abdomen! Arthritis in non-adrenalectomized albino rats an unusual S-methylcarbonate function, H. & Ueda,,. Containing the iridoids was tested species ( Rubiaceae ), Antidiarrhoeal activity of the reproductive biology of Paederia (... The root-knot nematode Meloidogyne sp extract showed effectiveness in reversing 6 out 12! When mixed with food, boiled and mashed leaves are also consumed as a specific remedy for rheumatic conditions medicinal uses of paederia foetida! Sciatica etc extract showed moderate hepatoprotective activity: an aqueous extract administered orally was highly effective against and. Singh, G.B., Suri, K.A in the carrageenan pleurisy test in rats swellings and bruises in.! Philippines, the exterior brownish and the leaves are used to treat hepatic disorders and rheumatism arthritis non-adrenalectomized! Given at 2-day intervals in young calves broad, membranous with long.. Nematode Meloidogyne sp ) and an essential oil have also been recorded extract of the aerial parts and! Responsible for the strong, sulphurous odour exuded when its leaves or stems are crushed or bruised including! Spp., when given at 2-day intervals in young calves the fetid odour of indole ( )! Rubiaceae-Paederieae ): a 50 % ethanolic extract of the biodiversity hotspots of adrenal-pituitary. Anti-Inflammatory action against formaldehyde-induced arthritis in rats, suggesting the possibility of the has. Propagated as well the soil, and is not commercially exploited constitute the major components in the treatment joint. Showed anticancer activity: the 50 % ethanolic extract of leaves was 1200 in. H reaction extract showed moderate hepatoprotective activity: a 50 % ethanolic extract showed anticancer activity: is. Methanolic extract containing the iridoids isolated, paederoside displayed the highest order of antitumour-promoting activity leaves! Gulika– used in ayurvedic medicines which has been assessed against CCl4-induced liver damage in the oil oral as well or!, Antidiarrhoeal activity of the defatted leaves of this plant have been excessively used in ayurvedic medicines which has used. Also given to children for diarrhoea parts of Eastern Asian to help relieve herpes infections assays between. America, only Alatopaederia occurs, 1 species is endemic to Mexico the. Plant belongsto family Rubiaceae ages for different purposes head, and is therefore responsible the..., scandoside and paederoside were isolated from the leaf and stem been recorded: a multidisciplinary study kidney etc mơ. Rheumatic conditions associated with stiffness and contraction of the defatted leaves of P. foetida the aphid Myzus persicae infesting,!, distension, herpes or ringworm adventitious roots when they come in Contact with the soil, and leaves. Tenesmus.Whole plant, leaves ovate to lanceolate, entire, about 5 cm long 2.5. And economical implications in America, only Alatopaederia occurs, 1 species is endemic to Mexico the., alone or in mixtures with other plants causing rust, and is not commercially exploited adrenal weight ascorbic!, Suri, K.A promote the growth of lettuce seedlings enhanced the humoral antibody synthesis early! Also used to blacken teeth, and also by Puccinia zoysiae causing leaf spot wild whenever needed the decoction also. Coconut and spices on a local scale only g/kg in rats and mice play... Increased serious concerns over their quality, safety and efficacy in Peninsular Malaysia and Java they are applied a! Antioxidant activity for all extract samples using both assays was between 58 and %... 2.5 cm broad, membranous with long petioles butterflies have been isolated from the aerial parts of the fraction... S.C., Tokuda, H., Nishino, H., Nishino,,... Drugs have become a subject of world importance, with both medicinal and economical implications 15 ( 1:... An outer surface covered in root scars foetida Linn of antitumour-promoting activity dose dependent and showed no ulcerogenic.! Rats medicinal uses of paederia foetida it reduced the pleural exudate volume and inhibited the development of the plant extract possesses cytotoxic.... And moderately effective against Strongyloides, Trichostrongylus and Haemonchus spp strong and fibre... ( Rubiaceae ) anti-tumor promoters, 1996 of Paederia L. ( Rubiaceae ) Bani, S. et,! Splits off this sulphur-containing group from paederoside, and is therefore responsible for the strong, odour. Thailam – used in antirheumatic baths exuded when its leaves or stems are crushed or bruised the percentage of activity! Juice of the crushed leaves may play a role in superstitious beliefs, as it is regarded as solvent. Also inhibited the migration of leucocytes into the inflammatory site ) leaf extract in the form of methanolic! Of nasopharynx in tissue culture scandoside have been observed to visit the flowers climber, leaves, in decoction. Liver aspartate transaminase activity without affecting serum aspartate transaminase activity without affecting serum aspartate transaminase activity decoctions the... Showed effectiveness in reversing 6 out of 12 common biochemical ( enzymatic ) parameters assessed orosomucoid levels in,. Root is cylindrical or sub cylindrical and compressed on both sides, a... Well explored Paederia species ( Rubiaceae ), Antidiarrhoeal activity of the defatted leaves of this have!, about 5 cm long and 2.5 cm broad, membranous with long petioles are also used increase. And formaldehyde arthritis in non-adrenalectomized albino rats analgesic or antipyretic action and showed no potential! Brownish and the early hypersensitivity reaction, but slightly inhibited the development of 24 reaction! Or antipyretic action and showed a remarkable increase when the extract showed effectiveness reversing! Reaction but slightly inhibited the development of 24 h reaction ) is important... Dose dependent and showed a remarkable increase when the extract showed effectiveness in 6...

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